Manning has a difficult schedule this year and it starts Week 1 against the Pittsburgh Steelers. The good news for Manning is that James Harrison has already been ruled out. The bad news is that the other Steelers defenders haven't been. Manning will look to develop rapport with his tight ends and Eric Decker early in the game to get into a flow. If that can happen, then he should be fine. He's the definition of a risky play this Week though.